METHYL (TRIMETHYLSILYL)ACETATE
methyl (trimethylsilyl)acetate
CAS: 2916-76-9
Molecular Formula: C6H14O2Si
METHYL (TRIMETHYLSILYL)ACETATE - Names and Identifiers
METHYL (TRIMETHYLSILYL)ACETATE - Physico-chemical Properties
| Molecular Formula | C6H14O2Si |
| Molar Mass | 146.26 |
| Density | 0.891g/mLat 25°C(lit.) |
| Boling Point | 38-39°C13mm Hg(lit.) |
| Flash Point | 91°F |
| Vapor Presure | 6.02mmHg at 25°C |
| Specific Gravity | 0.890 |
| BRN | 1098961 |
| Storage Condition | Flammables area |
| Sensitive | 2: reacts with aqueous acid |
| Refractive Index | n20/D 1.414(lit.) |
METHYL (TRIMETHYLSILYL)ACETATE - Risk and Safety
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3272 3/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | No |
| HS Code | 29319090 |
| Hazard Class | 3.1 |
| Packing Group | II |
METHYL (TRIMETHYLSILYL)ACETATE - Introduction
Methyl trimethylsilylacetate is an organic compound with the chemical formula C7H16O2Si. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble with organic solvents (such as ethers, alcohols and chlorinated hydrocarbons), insoluble in water
-Boiling point: about 87-89 ° C
-Density: approx. 0.78g/cm³
Use:
-Trimethylsilylacetic acid methyl ester is an important organic synthesis compound, often used as a reagent and intermediate.
-It can be used for deprotection reactions in organic synthesis, such as deprotection of esters.
-can also be used as a solvent and reaction substrate in organic synthesis.
Method:
The preparation of methyl trimethylsilylacetate can generally be carried out by the following steps:
1. First, methyl chloroformate (methyl chloroformate) is reacted with trimethylchlorosilane (trimethylchlorosilane) to obtain trimethylsilyl chloroacetate (trimethylsilyl chloroacetate).
2. Then, under the catalysis of alkali, methyl trimethylsilylchloroacetate is reacted with alcohol to generate methyl trimethylsilylacetate.
Safety Information:
-Trimethylsilyl methyl acetate can cause eye and skin irritation, so avoid contact with skin and eyes when in contact.
-It should be kept away from high temperatures, open flames and oxidants.
-When handling, please wear appropriate protective gloves and eye protection.
-In case of contact, immediately flush the affected area with plenty of water and seek medical help.
Nature:
-Appearance: colorless liquid
-Solubility: Soluble with organic solvents (such as ethers, alcohols and chlorinated hydrocarbons), insoluble in water
-Boiling point: about 87-89 ° C
-Density: approx. 0.78g/cm³
Use:
-Trimethylsilylacetic acid methyl ester is an important organic synthesis compound, often used as a reagent and intermediate.
-It can be used for deprotection reactions in organic synthesis, such as deprotection of esters.
-can also be used as a solvent and reaction substrate in organic synthesis.
Method:
The preparation of methyl trimethylsilylacetate can generally be carried out by the following steps:
1. First, methyl chloroformate (methyl chloroformate) is reacted with trimethylchlorosilane (trimethylchlorosilane) to obtain trimethylsilyl chloroacetate (trimethylsilyl chloroacetate).
2. Then, under the catalysis of alkali, methyl trimethylsilylchloroacetate is reacted with alcohol to generate methyl trimethylsilylacetate.
Safety Information:
-Trimethylsilyl methyl acetate can cause eye and skin irritation, so avoid contact with skin and eyes when in contact.
-It should be kept away from high temperatures, open flames and oxidants.
-When handling, please wear appropriate protective gloves and eye protection.
-In case of contact, immediately flush the affected area with plenty of water and seek medical help.
Last Update：2024-04-10 22:29:15
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View History
METHYL (TRIMETHYLSILYL)ACETATE
3-PHENOXYPROPIONIC ACID
氯化镧(III)双(氯化锂)络合物 溶液,LANTHANUM(III) CHLORIDE BIS(LITHIUM CHLORIDE) COMPLEX SOLUTION
1-碘乙基环己基碳酸酯
N2-(((9H-芴-9-基)甲氧基)羰基)-N6-甲酰基-L-赖氨酸
弱酸性丙烯酸系阳离子交换树脂
佛尔酮(二异亚丙基丙酮)
9-PHENYLCARBAZOLE
二氢朐腺嘧啶
8-氟咪唑并[1,2-A]吡啶-2-羧酸
3-PHENOXYPROPIONIC ACID
氯化镧(III)双(氯化锂)络合物 溶液,LANTHANUM(III) CHLORIDE BIS(LITHIUM CHLORIDE) COMPLEX SOLUTION
1-碘乙基环己基碳酸酯
N2-(((9H-芴-9-基)甲氧基)羰基)-N6-甲酰基-L-赖氨酸
弱酸性丙烯酸系阳离子交换树脂
佛尔酮(二异亚丙基丙酮)
9-PHENYLCARBAZOLE
二氢朐腺嘧啶
8-氟咪唑并[1,2-A]吡啶-2-羧酸